This is a Request for Quotations (RFQ) for bioinformatics analysis of livestock genomics. The U. S. Food and Drug Administration (FDA) Center for Veterinary Medicine (CVM) requires external support for visual validation of genomic variants in CRISPR-Cas9 gene-edited swine samples and generation of CRISPRME-ready input files for cattle, chicken, and swine. The period of performance is one year, from July 15, 2026, to July 14, 2027. The acquisition is a total small business set-aside. All data transfers must occur via PrecisionFDA. The contractor must perform visual validation of genomic variants and generate breed-specific VCFs compatible with CRISPRME software. Deliverables include validation reports, breed-specific VCFs, scripts, and workflows. The work is to be performed at the contractor's facility within the United States. No travel is required.
Key deliverables are due at various times, with final reports and packages due at least 30 business days before the contract period ends. For example, the final validation results are due 30 business days before the end of the contract period.
Payment will be made by the government after acceptance of deliverables. Invoices must be submitted electronically through the U. S. Department of Treasury's Invoice Processing Platform (IPP).
Contractors must assign personnel with demonstrated expertise in bioinformatics analysis of whole genome sequencing data, variant calling and validation, structural variant analysis, VCF file format, and preferably CRISPR-Cas9 genome editing technologies and swine genomics.
Late deliverables may be rejected at the government's discretion. Rejected deliverables must be corrected and resubmitted within 10 business days.
No site visit is required as the work is to be performed at the contractor's facility.
No sample submission is required.
Failure to meet performance standards, deliverable requirements, or adhere to data security and transfer protocols could lead to rejection of deliverables or contract termination.
