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Bioanalytical Science/ Drug Testing/ Analytical Testing
AJ11-- Pharmacokinetic Studies - Page 2 of 2 James A. Haley VA Medical Center, **** Bruce B. Downs Blvd. , Tampa, Florida ****, intends to solicit emergency sole source to Charles River Laboratories for CRO services for pharmacokinetics and toxicity studies of NPC86. Charles
CRO services for pharmacokinetics and toxicity studies of NPC86 Development of an HPLC MS/MS method for quantifying NPC86 in mouse plasma; Optimization and qualification of an LC- MS/MS RGA2 method for quantifying NPC86 in mouse tissues; Pharmacokinetic and biodistribution study of NPC86 in C57BL6 mouse.
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James A. Haley VA Medical Center intends to solicit an emergency sole source to Charles River Laboratories for CRO services. Services include developing HPLC MS/MS and LC-MS/MS methods for NPC86 quantification in mouse plasma and tissues, and conducting a pharmacokinetic/biodistribution study in C57BL6 mice. Personnel must have specific qualifications, including B. S. , M. S. , or Ph. D. for bioanalytical scientists. Information must be received by **** at 10:00 am EST.
Bioanalytical scientists must have a B. S. , M. S. , or Ph. D. and experience with HPLC LC-MS method development. bioanalytical scientists must be experienced with hplc lc ms method development, tissue extraction, calibration curves, assay qualification, and regulated documentation and must have a b. s, m. s, or ph. d.
Mouse PK/PD Study Services for NNMT Inhibitors - ( i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12. 6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being
Mouse PK/PD Study Services Mouse PKPD study services for NNMT inhibitors, including animal handling, dosing, biological sample collection, bioanalytical testing, pharmacokinetic analysis, data management, and reporting for 10 test articles.
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The NIH seeks commercially available mouse PKPD study services for NNMT inhibitor test articles. The scope includes single-dose oral (PO) and intravenous (IV) studies in mice, bioanalytical testing for parent compound and 1MNA, PK parameter calculation, and final report delivery within three weeks of study completion. All data generated is confidential and property of the government. Responses must be received by August 24, 8:00 am EST.
The period of performance shall be up to three 3 months from receipt of the purchase order.
All invoices must be uploaded into the invoicing processing platform ipp https:www. ipp. gov. The invoice must match the line item description on the purchase order. It must also state that payment is to be made using a threeway match.
The government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the government, price and other factors considered.
Responses must include the unique entity identifier uei, taxpayer identification number tin, and business size certification.
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